I have found the utilization of Turn-It-In to greatly reduce the ability for students to cheat on assignment and research papers. It also assists in catching students who copy and paste material from the internet and plagiarize.
One neat feature that Turn-It-In does is upon submitting an assignment it reviewes to see not only if the students response was copied from the internet but also from other students current/past responses.
This has allowed me to capture many times where a student tries to submit the same research paper for multiple classes and in one circumstance where a student was turning in a paper previously submitted by a student a year ago in a different class.